現貨moradec AM-106-PB說明書(shu)
αMFc CL PBD
具有可裂解連接子的抗小鼠IgG Fc PBD抗體(ti)
目錄號：AM-106-PB
αMFc CL PBD是抗小鼠IgG Fc特異性抗體(ti) ，與(yu) 吡咯並二氮雜平（PBD）結合，具有可裂解接頭。抗體(ti) 部分是對小鼠IgG的Fc區具有特異性的多克隆抗體(ti) ，並且它也對大鼠IgG的Fc區具有交叉反應性。吡咯並二氮卓（PBD）是一種細胞毒性小分子，它與(yu) 小凹槽結合，並與(yu) 的特定位點交叉連接。連接PBD和抗體(ti) 的可裂解接頭在細胞外液中是穩定的，但一旦綴合物通過內(nei) 吞作用進入細胞，就會(hui) 被內(nei) 體(ti) 中的組織蛋白酶裂解。
| Anti-Mouse IgG Fc-PBD Antibody with Cleavable Linker | Catalog Number: AM-106-PB |
| αMFc-CL-PBD is anti-mouse IgG Fc specific antibody conjugated to pyrrolobenzodiazepine (PBD) with a cleavable linker. The antibody portion is a polyclonal antibody which is specific to the Fc region of mouse IgGs, and it is also cross-reactive to the Fc region of Rat IgGs. Pyrrolobenzodiazepine (PBD) is a cytotoxic small molecule which binds to minor groove and cross-links specific sites of . The cleavable linker connecting PBD to the antibody is stable in extracellular fluid, but is cleaved by cathepsin in endosome once the conjugate has entered a cell via endocytosis. | |
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